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Graduate seminar, wednesdays 10a - 1p, BOUS 109
3 credits


1/22 -- Introduction, Sign-ups; Review of SLI/dyslexia for next week [CANCELLED]


1/29 -- SLI/dyslexia:
Amanda R (1) and Beata K (1)

1). Szalkowski & Fitch. 2011.
Candidate Dyslexia Susceptibility Genes and Disorders of Neuronal Migration: Behavioral Effects of Cortical Dysgenesis in a Rodent Model.pdf

2) White et al. 2006.pdf
Singing mice, songbirds and FOXP2.

Overview of dyslexia and SLI model papers, Intro to ASD

2/5 -- Autism/Fragile X: Amanda R (2) and Hector C. (1)  [CANCELLED, present next week]

1) Bernardet & Crusio. 2006.
Fmr1 KO mice as a possible model of autistic features.

2) Silverman et. al. 2010.pdf
Behavioral phenotyping for mouse models of autism.

3) Yoo.etal.Shank.2013.pdf
Shank mutant mice as an animal model of autism.

2/12 -- Williams syndrome (WBS): Beata K. (2) and Hector C. (2)  

1) Caposello.etal.2011.pdf

Growth defects and impaired cognitive–behavioral abilities in mice with knockout for Eif4h, Williams-Beuren syndrome critical region.

2) Hua.etal.2009.pdf
Induced chromosome deletions cause hypersociability and other features of Williams–Beuren syndrome in mice.

WEEKS 2&3 (combined) PDF

Overview,  papers on ASD and Williams

2/19 -- Down Syndrome: Beata K. (3) and Amanda R. (3)  

1) Rueda.etal.2012.pdf

Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities.

2) Ruparelia.etal.2013.pdf
Aging and intellectual disability: Insights from mouse models of Down syndrome.

Overview of Down's papers, Intro to PD

2/26 -- Parkinsons disease: Sam Y (1) and Sam P (a)  

1) FlemingReview.2005.pdf

Genetic mouse models of Parkinsomism: Strengths and limitations.

2) Salamone.2008.pdf

Neurochemical and pharmacologic models of PD in rodents

Optional review of clinical PD symptoms.

Overview of PD papers, Intro to depression

3/5 -- Depression: Sam Y (2) and Hector C. (3) 

1) Barkus.2013.pdf
Genetic mouse models of depression (hand-copied book chapter, but very recent)

2) Overstreet&Wegener.2013.pdf
The Flinders sensitive line rat model of depression

Kim et al., 2014

Optional, Pitx3 deficient mice as an animal model of co-morbid depressive disorder and parkinsonianism

3/12 -- ADD/ADHD: Haley G (1) and Hector C (4)

1. Gainetdinov, 2010.
Strengths and limitations of genetic models of ADHD

2. Tripp & Wickens, 2012.

Reinforcement, dopamine and rodent models in drug development for ADHD

WEEKS 6 & 7 Combined PDF


3/26 -- Alzheimers/generalized dementia
: Sam Y. (3) and Hector. C (5)

1. Hall & Roberson, 2012
Mouse models of Alzheimers disease

2. Jiwa et al., 2010

Experimental models of vascular dementia and vascular cognitive impairment: a systematic review


4/2 -- Schizophrenia: Sam Y (4) and Amanda R. (4)

1. Mutant models for genes associated with schizophrenia
Desbonnet et al., 2009

2.  Behavioral phenotypes in schizophrenic animal models with multiple combinations of genetic and environmental factors.
Hida et al., 2013

4/9 -- Cerebral palsy: Sam Y (5) and Haley G (2) 

1. Prenatal and postnatal animal models of immune activation: Relevance to a range of neurodevelopmental disorders.
Harvey & Boksa, 2012

2. Evidence for therapeutic intervention in the prevention of cerebral palsy: Hope from animal model research.
Nguyen et al., 2013

4/16 -- Stroke - adult: Haley G. (3) and Beata K (4)

1. Assessing post-stroke behavior in mouse models of focal ischemia.
Balkaya et al., 2013 

2. Deficits in auditory, cognitive and motor processing following reversible cerebral artery occlusion in mice.
Truong et al., 2012

4/23 -- Neonatal HI/HIE: Amanda S. (a) and Haley G. (4) 

1. Brief update on animal models of hypoxic-ischemic encephalopathy and neonatal stroke.
Northington, 2014.

2. Neonatal encephalopathy: pre-clinical models in neuroprotection.
Patel et al., 2014.

Animal models of hypoxic-ischemic brain damage in the newborn.
Yager, 2004.

4/30 -- Epilepsy/Seizure disorders/Rett: Haley G. (5) and Amanda R. (5)

1. Pre-clinical research in Rett syndrome: setting the foundation for translational success.
Katz et al., 2012

2. Pathogenesis of epilepsy: Challenges in animal models.
Yin et al., 2013